http://osipro.henkel.buildingonline.com/workbook-for-elseviers-veterinary-assisting-textbook-e-book.php Skin problems, osteogenesis, angiogenesis or fracture healing are some examples of tissue disorders that can be restored by using stem cells therapy and nanotechnology. Nano-structured metal-semiconductor-metal photodetector for sensor network systems. The advanced and smart ways to produce complex nano-structures have incorporated new capabilities in various aspects of science and technology where structures on nano-meter scales are desirable including high-speed communication and sensor networks, and future biomedical sensors and detectors.
In recent years, there has been a growing interest towards the miniaturization of optical and electrical components with faster and more efficient performance. The development of nano-materials and nano-structures design provides great opportunity for building multifunctional sensing elements which are smaller and more efficiently incorporated.
Furthermore they have other useful characteristics like reduced production cost and minimized power consumption.
Wireless sensor network systems have been identified as one of the most important technologies for the 21st century Chong et. It can be deduced from its name that sensor network systems are composed of several sensor nodes, where each component is responsible for a function in the whole system, where it can consist of different kinds of sensors such as, thermal, visual, biomedical, infrared, acoustics, etc.
In addition, the material could gradually imbibe exudates and dead debris from wound site. Opsonizing proteins modulated microparticle uptake, and integrin Mac-1 and RGD-binding integrins were found to control microparticle uptake in an opsonin-dependent manner. In this report, we demonstrate that by phenotype screen we could identify bioactive natural products whose properties could be harnessed for developing biomaterials with favorable physico-chemical characteristics. Mertz, P. Resume : Titanium and its alloys have been widely used for dental implants due to their non-toxicity, biocompatibility, corrosion resistance, and mechanical properties. Observed biological effects may result not only from different chemical composition, but also from diverse wettability.
Recent wireless communication system development requires a concurrent speedy advancement of sensors characteristics as well as the system performance. Therefore, it is very important to make the progress in sensors design with tiny dimensions, suitable for communication over a sensor network system with specified purposes such as, monitoring different parameters, namely humidity, temperature, light in household, cities, and different environments Ian-Akyildiz et al.
The main focus of this review is to design and model an optimized plasmonics-based metal-semiconductor-metal photodetectors MSM-PDs with sub-wavelength architectures that is useful for high-speed optical communication systems and sensor network systems. Nano-structures designed on top of the electrodes trigger surface plasmon polaritons SPPs excitation and enable routing and manipulation of the light to be eventually trapped into the device active region.
Organic-inorganic antimicrobial nanostructures for health care applications. In recent years, the drug resistant microorganisms are a serious and increasing public health problem. New strategies for controlling bacteria activity are urgently needed and nanomaterials can be a very promising approach, as the small size of the particle gives large surface area and consequently reactivity and in many cases toxicity increases substantially.
The most tested metallic nanoparticles are silver, copper, gold, aluminum, titanium, iron, zinc, bismuth and others. Some of these metals have been coated onto several other materials. Another strategy is to incorporate these metals into a substrate such as polymethyl methacrylate forming organic-inorganic antimicrobial nanostructures. With respect to bacteria and fungi, the most frequent candidates for microbial experiments are: Staphylococcus aureus, Pseudomonas aeruginosa, Escherichia coli, Klebsiella pneumonia, Bacillus subtilis among other species. The antimicrobial potential of these nanostructured particles, their mechanism of action and health care applications are presented and discussed at length in this review.
Nanostructures and their application in antimicrobial drug delivery system. As multiresistant and pan-resistant infections continue to emerge, and because the development of novel antimicrobial drugs is a slow process, nanotechnology offers valuable alternatives for fighting resistant bugs, mainly by improving the therapeutic effect of current antimicrobials. Antibiotic resistance is one of the greatest global health threats of the 21st century, but nanotechnology is offering new solutions to the problem. Nanostructured biomaterials, nanoparticles in particular, have unique physicochemical properties such as ultra small and controllable size, large surface area to mass ratio, high reactivity, and functionalizable structure.
These properties can be applied to facilitate the administration of antimicrobial drugs, thereby overcoming some of the limitations in traditional antimicrobial therapeutics. Carbon-based nanomaterials such as fullerenes, carbon nanotubes CNTs especially single-walled carbon nanotubes SWCNTs and graphene oxide GO nanoparticles show potent antimicrobial properties.
Nanocoating and shuttle systems have shown great promise in vitro and animal models. Noble metals nanostructures, particularly silver, have attracted much attention in the fields of medicine due to their unique properties which are strongly dependent on the size and shape of metal nanomaterials. Recent development of nanocarriers, improved the drug therapy of different diseases, together with the mechanisms of microbial inhibition.
Applications of transition metal nanoparticles in antimicrobial therapy. Arunachalam Dinesh Karthik, Kannappan Geetha. Nanotechnology is expected to open some new aspects to fight and prevent diseases using atomic scale tailoring of materials. The ability to uncover the structure and function of bio systems at the nanoscale, stimulates research leading to improvement in biology, biotechnology, medicine and healthcare. The size of nanomaterials is similar to that of most biological molecules and structures; therefore, nanomaterials can be useful for both in vivo and in vitro biomedical research and applications.
The integration of nanomaterials with biology has led to the development of diagnostic devices, contrast agents, analytical tools, physical therapy applications, and drug delivery vehicles. AB - In this chapter, we describe recent advances in the noninvasive optical imaging of stem cells using photonic crystal label-free biosensor surfaces. Abstract In this chapter, we describe recent advances in the noninvasive optical imaging of stem cells using photonic crystal label-free biosensor surfaces.
Fingerprint Optics and Photonics. Optical Imaging. Biocompatible Materials. Cell Differentiation. Stem Cells. Biosensing Techniques. Keywords Differentiation Live cell imaging Noninvasive photonic crystal biosensor Stem cells. Elsevier Inc.. Elsevier Inc. In addition, the use of high-throughput set-ups for studying various cellular behaviors such as adhesion, growth, proliferation, and differentiation for tissue engineering applications will be covered. In addition to microarray platforms, microfluidic high-throughput systems for controlling cell behavior will also be highlighted by this session.
Functional Biomaterials to Control and Direct Cellular Function Functional Biomaterials to Control and Direct Cellular Function This session solicits abstracts that focus on the development functional biomaterials for tissue engineering applications. Specifically, studies that investigate biomaterial-directed cellular response in the absence of external factors e. These studies include development of novel biomimetic approaches for the generation of tissue scaffolds with physicochemical properties e.
Further, this session will also showcase in vivo studies that demonstrate the clinical translational capability of next generation functional biomaterials. Lastly, studies that focus on the investigation of biomaterial-based mechanisms that modulate cellular response are of interest.
Biomaterials for Drug-Device Combinations Biomaterials for Drug-Device Combinations This symposium will focus on the development of products that are a combination of both a device and a drug. These types of innovations are anticipated to have an expanding role in healthcare. Disease areas where device-drug combinations are becoming increasingly important include cardiology, infection, diabetes, neurology, and oncology, to name a few.
This session aims to provide a broad overview of the field and welcome speakers to provide insight into cutting edge new technology and research. The incentives for developing drug or cell -based therapy to address this problem are huge, yet still unmet due to complex physiological barriers. The first invited speaker is a clinician and the second a biomedical engineer. Solicited abstracts will provide industrial and academic researchers a forum for presenting emerging technologies in the field.
Monitoring and Evaluation of Biomaterials and their Performance In Vivo. Book • Edited by: Roger J. Narayan. Browse book content. About the book. Purchase Monitoring and Evaluation of Biomaterials and their Performance In Vivo - 1st Edition. Print Book & E-Book. ISBN
While current membranes act primarily in a passive manner, new and developing membranes are providing adjunctive bioactive activities to stimulate healing, bone formation and or infection. Additional functionalities of this new generation of smart dental materials have focused on both clinical and biologicalfunctions. The former include improved aesthetics, material strength, and adhesion. Besides superior biocompatibility, biomaterial properties that promotetherapeutic responses include antimicrobial activity and improved pulp-dentin healing, among others.
This session will focus on novel biomaterials to improve patient care for oral, dental, and craniofacial applications. Next-Generation Biomaterials for Treatment of Type 1 Diabetes Next-Generation Biomaterials for Treatment of Type 1 Diabetes Type 1 diabetes is an autoimmune disease in which the insulin-producing beta cells of the pancreas are destroyed.
Examples include: i materials delivering bioactive or immunomodulatory therapies, ii biomaterials addressing islet hypoxia, inflammation, and vascularization, iii biomaterial strategies for delivery of renewable sources of beta cells, and iv advancements in implantable glucose sensing technologies. Cost are high as are complications and morbidity. Most all dialysis technology involves biomaterials.
This session will examine new biomaterials technologies that can improve outcomes and reduce costs. Blood compatibility, membrane technologies, blood access, skin healing, sorbents and non-fouling technologies are of special interest for nextgeneration dialysis. Biomaterials for Therapeutic Drug Delivery Biomaterials for Therapeutic Drug Delivery Controlled release approaches have the potential to effectively treat a variety of medical conditions, while avoiding complications such as off-site toxicity and drug-resistance.
Approaches can include localized, depot-based methods as well as targeted, systemic treatments. These local delivery systems have tremendous applications in orthopaedic implants, fracture fixation devices, dental implants, cardiovascular devices, craniofacial implants, ophthalmic implants, cochlear implants, and neural devices.
This session will cover a wide range of delivery platforms that are currently available for different implant surfaces. This session will also highlight the importance of different surface characterization techniques to study such coatings. A special emphasis will be provided to the implant coating technologies that have been translated into preclinical and clinical products. Non-Viral Delivery for Gene Therapy and Editing Non-Viral Delivery for Gene Therapy and Editing Targeted genome editing using programmable nucleases has recently rapidly transformed from a technique on the bench to a potential avenue for the treatment of genetic disorders and diseases.
Three main types of nucleases, including zinc finger nucleases ZFNs , transcription activator-like effector nucleases TALENs , and the clustered, regularly interspaced, short palindromic repeat CRISPR -associated endonuclease Cas9 have been harnessed to introduce precise and specific genome sequence change at virtually any genome locus of interest. The therapeutic relevance of genome editing, however, is challenged by the safe and efficient delivery of nuclease into targeted cells ex vivo and in vivo.
This symposium will cover the fundamentals, perspective and challenge of genome editing, and highlight the recent advances that have been made on non-viral delivery of genome-editing nucleases for therapy. Gasotransmitter Delivery from Biomaterials Gasotransmitter Delivery from Biomaterials Nitric oxide NO , carbon monoxide CO , hydrogen sulfide H2S and other small gaseous molecules are now co-classified as endogenous gasotransmitters with profound effects on mammalian physiology and major implications in therapeutic applications. Although gasotransmitters have wide ranging therapeutic potential, their clinical use is limited by their gaseous nature, systemic toxicity, off-target effects, short half-life, and extensive reactivity.
While there are many small molecules that can slowly release gasotransmitters under physiological conditions, most are quickly cleared in vivo and cannot target specific sites. Therefore, biomaterials that can controllably deliver gasotransmitters being developed. This session will explore the delivery and therapeutic potential of small gaseous signaling molecules from biomaterials. These materials have the potential to act rapidly and effectively, while avoiding various complications e. As in previous years, the biomaterials education challenge will encourage SFB student chapters and other student clubs or groups to develop innovative and practical approaches to biomaterials education.
Student teams will be tasked with developing an educational module for middle school science classes that highlight the fundamentals aspects of biomaterial system. Glycomaterials Glycomaterials Carbohydrates, including monosaccharides, oligosaccharides, polysaccharides, and their conjugates, are key structural and signaling elements in living systems.
Understanding the roles of carbohydrates in nature has led to increasing opportunities to leverage them as both therapeutic targets and active components for biomedical and biotechnological applications. Carbohydratecontaining biomaterials i. This session will highlight recent advances in the synthesis, characterization, and use of glycomaterials to interrogate and harness the biological activity of carbohydrates.
Particular emphasis will be placed on synthetic glycomaterials to probe glycocalyx function, modulate protein activity, and engage the immune system for infection prophylaxis and immunotherapy.
Multifunctional Biomaterials: Recent Developments and Future Directions Multifunctional Biomaterials: Recent Developments and Future Directions There are increasing demands for biomaterials that are responsive to local stimuli e. Various approaches have been studied to develop multifunctional biomaterials including 3D printing, electrospinning, self-assembly, photolithography, and so on.
In this symposium, the recent developments and breakthroughs of biomaterials with multiple biological functions and the methods to create such biomaterials will be reported along with the challenges and translational studies. Mixed presentations from the U. Metallic Biomaterials for Medical Implants Metallic Biomaterials for Medical Implants Metallic biomaterials have been widely used in many medical implants. Traditional metallic biomaterials such as Titanium, Stainless Steel, and CoCr have been used in various implantable devices.
Recently, more innovative metallic materials have been developed, which include smart materials and biodegradable metals. Novel fabrication technologies or applications for metallic biomaterials will include materials for use in cardiovascular, neurovascular, and dental applications, as well as various prosthesis, among others.
Click Chemistry in Biomaterials Click Chemistry in Biomaterials Click chemistry has emerged as a powerful tool for biomaterial synthesis. A key advantage of chemical reactions fitting the click chemistry paradigm is that they are highly selective and, thus, provide greater control over material structure and properties.
Click reactions are also fast, efficient, proceed under mild conditions, and produce only inoffensive byproducts.
Because of these advantages, click reactions are now being leveraged to synthesize and functionalize novel drug delivery systems, tissue engineering scaffolds, and biosensors. This session aims to highlight the role of click chemistry in developing novel biomaterials for these and other applications. Submissions describing efforts to expand the click chemistry toolkit in biomaterials and to elucidate the intricacies, unique advantages, and challenges of specific click reactions are also of interest.
Engineering Biomaterials for Translational Pulmonary Research Engineering Biomaterials for Translational Pulmonary Research Precisely designed biomaterials are a powerful tool for reproducing and studying the complex structure, mechanics and composition of pulmonary tissues. Here, we invite contributions that design, develop and implement biomaterial solutions for the diagnosis and treatment of acute and chronic pulmonary diseases and complications. Specific areas of interest are regenerative medicine, controlled therapeutic delivery, use of biomaterials for acute pulmonary complications, development of biomaterials for thoracic surgery and personalized disease modeling.
Biomaterials for Epithelium Substitutes Biomaterials for Epithelium Substitutes This session is dealing with various subjects related to fabrication, characterization, and clinical translation of novel biomaterials substituting epithelium, such as skin, cornea, bronchi, and other epithelial tissues.
Uniqueness of these epithelium is multilayered structures allowing different cell types are functioning, which have been extensively studied in fabricating artificial, cornea, alveolar epithelium, and , for drug screening and cosmetic science as well as complete tissue regeneration of the related tissues. Industry as well as academia-based researches are welcomed submit abstracts related to studies on any epithelium or parts of epithelium.
This symposium will highlight recent efforts in bioelectronics, including fabrication advances for improved properties such as size, softness, flexibility, degradability and biocompatibility as well as investigating their use in new applications. This is leading to major advances in biomaterials fabrication in terms of new materials and design strategies and redefining the manufacturing process. Further, the low-cost of many of these technologies enables a wider range of scientists and engineers to leverage these capabilities in there own labs, even in resource limited and educational environments.
Immunomodulatory Biomaterials Immunomodulatory Biomaterials Therapeutic modulation of the immune system is the emerging paradigm in medicine. For example, immunotherapy holds the promise of a cure for cancer, and is poised to expand into other therapeutic areas, such as inflammatory disorders, autoimmune diseases etc.